Racemorphan
Brand names,
Racemorphan
Analogs
Racemorphan
Brand Names Mixture
Racemorphan
Chemical_Formula
C17H23NO
Racemorphan
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Racemorphan
fda sheet
Racemorphan
msds (material safety sheet)
Racemorphan
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Racemorphan
Molecular Weight
257.371 g/mol
Racemorphan
Melting Point
198-199 oC
Racemorphan
H2O Solubility
1840 mg/L
Racemorphan
State
Solid
Racemorphan
LogP
3.986
Racemorphan
Dosage Forms
Tablet
Racemorphan
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Racemorphan
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Racemorphan
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Racemorphan
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Racemorphan
Patient Information
No information avaliable
Racemorphan
Organisms Affected
Humans and other mammals