Levorphanol Dl-Form
Brand names,
Levorphanol Dl-Form
Analogs
Levorphanol Dl-Form
Brand Names Mixture
Levorphanol Dl-Form
Chemical_Formula
C17H23NO
Levorphanol Dl-Form
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Levorphanol Dl-Form
fda sheet
Levorphanol Dl-Form
msds (material safety sheet)
Levorphanol Dl-Form
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Levorphanol Dl-Form
Molecular Weight
257.371 g/mol
Levorphanol Dl-Form
Melting Point
198-199 oC
Levorphanol Dl-Form
H2O Solubility
1840 mg/L
Levorphanol Dl-Form
State
Solid
Levorphanol Dl-Form
LogP
3.986
Levorphanol Dl-Form
Dosage Forms
Tablet
Levorphanol Dl-Form
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Levorphanol Dl-Form
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Levorphanol Dl-Form
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Levorphanol Dl-Form
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Levorphanol Dl-Form
Patient Information
No information avaliable
Levorphanol Dl-Form
Organisms Affected
Humans and other mammals