Aromarone
Brand names,
Aromarone
Analogs
Aromarone
Brand Names Mixture
Aromarone
Chemical_Formula
C17H23NO
Aromarone
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Aromarone
fda sheet
Aromarone
msds (material safety sheet)
Aromarone
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Aromarone
Molecular Weight
257.371 g/mol
Aromarone
Melting Point
198-199 oC
Aromarone
H2O Solubility
1840 mg/L
Aromarone
State
Solid
Aromarone
LogP
3.986
Aromarone
Dosage Forms
Tablet
Aromarone
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Aromarone
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Aromarone
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Aromarone
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Aromarone
Patient Information
No information avaliable
Aromarone
Organisms Affected
Humans and other mammals