Dromoran
Brand names,
Dromoran
Analogs
Dromoran
Brand Names Mixture
Dromoran
Chemical_Formula
C17H23NO
Dromoran
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Dromoran
fda sheet
Dromoran
msds (material safety sheet)
Dromoran
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Dromoran
Molecular Weight
257.371 g/mol
Dromoran
Melting Point
198-199 oC
Dromoran
H2O Solubility
1840 mg/L
Dromoran
State
Solid
Dromoran
LogP
3.986
Dromoran
Dosage Forms
Tablet
Dromoran
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Dromoran
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Dromoran
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Dromoran
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Dromoran
Patient Information
No information avaliable
Dromoran
Organisms Affected
Humans and other mammals