Orphan

Orphan Brand names, Orphan Analogs

Orphan Brand Names Mixture

No information avaliable

Orphan Chemical_Formula

C₁₇H₂₃NO

Orphan RX_link

http://www.rxlist.com/cgi/generic2/levorphanol.htm

Orphan fda sheet

Orphan msds (material safety sheet)

Orphan MSDS

Orphan Synthesis Reference

Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.

Orphan Molecular Weight

257.371 g/mol

Orphan Melting Point

198-199 ^oC

Orphan H₂O Solubility

1840 mg/L

Orphan State

Solid

Orphan LogP

3.986

Orphan Dosage Forms

Tablet

Orphan Indication

For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate

Orphan Pharmacology

Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.

Orphan Absorption

Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.

Orphan side effects and Toxicity

LD₅₀=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.

Orphan Patient Information

No information avaliable

Orphan Organisms Affected

Humans and other mammals