Racemethorphanum
Brand names,
Racemethorphanum
Analogs
Racemethorphanum
Brand Names Mixture
Racemethorphanum
Chemical_Formula
C17H23NO
Racemethorphanum
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Racemethorphanum
fda sheet
Racemethorphanum
msds (material safety sheet)
Racemethorphanum
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Racemethorphanum
Molecular Weight
257.371 g/mol
Racemethorphanum
Melting Point
198-199 oC
Racemethorphanum
H2O Solubility
1840 mg/L
Racemethorphanum
State
Solid
Racemethorphanum
LogP
3.986
Racemethorphanum
Dosage Forms
Tablet
Racemethorphanum
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Racemethorphanum
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Racemethorphanum
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Racemethorphanum
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Racemethorphanum
Patient Information
No information avaliable
Racemethorphanum
Organisms Affected
Humans and other mammals