Levo-Dromoran
Brand names,
Levo-Dromoran
Analogs
Levo-Dromoran
Brand Names Mixture
Levo-Dromoran
Chemical_Formula
C17H23NO
Levo-Dromoran
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Levo-Dromoran
fda sheet
Levo-Dromoran
msds (material safety sheet)
Levo-Dromoran
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Levo-Dromoran
Molecular Weight
257.371 g/mol
Levo-Dromoran
Melting Point
198-199 oC
Levo-Dromoran
H2O Solubility
1840 mg/L
Levo-Dromoran
State
Solid
Levo-Dromoran
LogP
3.986
Levo-Dromoran
Dosage Forms
Tablet
Levo-Dromoran
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Levo-Dromoran
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Levo-Dromoran
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Levo-Dromoran
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Levo-Dromoran
Patient Information
No information avaliable
Levo-Dromoran
Organisms Affected
Humans and other mammals