Methorphinan

Methorphinan Brand names, Methorphinan Analogs

Methorphinan Brand Names Mixture

No information avaliable

Methorphinan Chemical_Formula

C₁₇H₂₃NO

Methorphinan RX_link

http://www.rxlist.com/cgi/generic2/levorphanol.htm

Methorphinan fda sheet

Methorphinan msds (material safety sheet)

Methorphinan MSDS

Methorphinan Synthesis Reference

Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.

Methorphinan Molecular Weight

257.371 g/mol

Methorphinan Melting Point

198-199 ^oC

Methorphinan H₂O Solubility

1840 mg/L

Methorphinan State

Solid

Methorphinan LogP

3.986

Methorphinan Dosage Forms

Tablet

Methorphinan Indication

For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate

Methorphinan Pharmacology

Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.

Methorphinan Absorption

Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.

Methorphinan side effects and Toxicity

LD₅₀=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.

Methorphinan Patient Information

No information avaliable

Methorphinan Organisms Affected

Humans and other mammals