Antalgin
Brand names,
Antalgin
Analogs
Antalgin
Brand Names Mixture
Antalgin
Chemical_Formula
C17H23NO
Antalgin
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Antalgin
Molecular Weight
257.371 g/mol
Antalgin
Melting Point
198-199 oC
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H2O Solubility
1840 mg/L
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State
Solid
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LogP
3.986
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Dosage Forms
Tablet
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Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Antalgin
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Antalgin
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Antalgin
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Antalgin
Patient Information
No information avaliable
Antalgin
Organisms Affected
Humans and other mammals