Cetarin
Brand names,
Cetarin
Analogs
Cetarin
Brand Names Mixture
Cetarin
Chemical_Formula
C17H23NO
Cetarin
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Cetarin
fda sheet
Cetarin
msds (material safety sheet)
Cetarin
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Cetarin
Molecular Weight
257.371 g/mol
Cetarin
Melting Point
198-199 oC
Cetarin
H2O Solubility
1840 mg/L
Cetarin
State
Solid
Cetarin
LogP
3.986
Cetarin
Dosage Forms
Tablet
Cetarin
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Cetarin
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Cetarin
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Cetarin
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Cetarin
Patient Information
No information avaliable
Cetarin
Organisms Affected
Humans and other mammals