Evoclin
Brand names,
Evoclin
Analogs
Evoclin
Brand Names Mixture
Evoclin
Chemical_Formula
C18H33ClN2O5S
Evoclin
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Evoclin
fda sheet
Evoclin
msds (material safety sheet)
Evoclin
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Evoclin
Molecular Weight
424.984 g/mol
Evoclin
Melting Point
255 oC
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H2O Solubility
30.6 mg/L
Evoclin
State
Solid
Evoclin
LogP
1.224
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Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Evoclin
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Evoclin
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
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Absorption
- 90% - oral
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side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Evoclin
Patient Information
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Organisms Affected
Enteric bacteria and other eubacteria