Clindesse
Brand names,
Clindesse
Analogs
Clindesse
Brand Names Mixture
Clindesse
Chemical_Formula
C18H33ClN2O5S
Clindesse
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Clindesse
fda sheet
Clindesse
msds (material safety sheet)
Clindesse
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Clindesse
Molecular Weight
424.984 g/mol
Clindesse
Melting Point
255 oC
Clindesse
H2O Solubility
30.6 mg/L
Clindesse
State
Solid
Clindesse
LogP
1.224
Clindesse
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Clindesse
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Clindesse
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clindesse
Absorption
- 90% - oral
Clindesse
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Clindesse
Patient Information
Clindesse
Organisms Affected
Enteric bacteria and other eubacteria