Clinda-Derm
Brand names,
Clinda-Derm
Analogs
Clinda-Derm
Brand Names Mixture
Clinda-Derm
Chemical_Formula
C18H33ClN2O5S
Clinda-Derm
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Clinda-Derm
fda sheet
Clinda-Derm
msds (material safety sheet)
Clinda-Derm
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Clinda-Derm
Molecular Weight
424.984 g/mol
Clinda-Derm
Melting Point
255 oC
Clinda-Derm
H2O Solubility
30.6 mg/L
Clinda-Derm
State
Solid
Clinda-Derm
LogP
1.224
Clinda-Derm
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Clinda-Derm
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Clinda-Derm
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clinda-Derm
Absorption
- 90% - oral
Clinda-Derm
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Clinda-Derm
Patient Information
Clinda-Derm
Organisms Affected
Enteric bacteria and other eubacteria