Clindamycin Phosphate
Brand names,
Clindamycin Phosphate
Analogs
Clindamycin Phosphate
Brand Names Mixture
Clindamycin Phosphate
Chemical_Formula
C18H33ClN2O5S
Clindamycin Phosphate
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Clindamycin Phosphate
fda sheet
Clindamycin Phosphate
msds (material safety sheet)
Clindamycin Phosphate
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Clindamycin Phosphate
Molecular Weight
424.984 g/mol
Clindamycin Phosphate
Melting Point
255 oC
Clindamycin Phosphate
H2O Solubility
30.6 mg/L
Clindamycin Phosphate
State
Solid
Clindamycin Phosphate
LogP
1.224
Clindamycin Phosphate
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Clindamycin Phosphate
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Clindamycin Phosphate
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clindamycin Phosphate
Absorption
- 90% - oral
Clindamycin Phosphate
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Clindamycin Phosphate
Patient Information
Clindamycin Phosphate
Organisms Affected
Enteric bacteria and other eubacteria