Clindamycine [Inn-French]
Brand names,
Clindamycine [Inn-French]
Analogs
Clindamycine [Inn-French]
Brand Names Mixture
Clindamycine [Inn-French]
Chemical_Formula
C18H33ClN2O5S
Clindamycine [Inn-French]
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Clindamycine [Inn-French]
fda sheet
Clindamycine [Inn-French]
msds (material safety sheet)
Clindamycine [Inn-French]
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Clindamycine [Inn-French]
Molecular Weight
424.984 g/mol
Clindamycine [Inn-French]
Melting Point
255 oC
Clindamycine [Inn-French]
H2O Solubility
30.6 mg/L
Clindamycine [Inn-French]
State
Solid
Clindamycine [Inn-French]
LogP
1.224
Clindamycine [Inn-French]
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Clindamycine [Inn-French]
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Clindamycine [Inn-French]
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clindamycine [Inn-French]
Absorption
- 90% - oral
Clindamycine [Inn-French]
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Clindamycine [Inn-French]
Patient Information
Clindamycine [Inn-French]
Organisms Affected
Enteric bacteria and other eubacteria