Cleocin Phosphate
Brand names,
Cleocin Phosphate
Analogs
Cleocin Phosphate
Brand Names Mixture
Cleocin Phosphate
Chemical_Formula
C18H33ClN2O5S
Cleocin Phosphate
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Cleocin Phosphate
fda sheet
Cleocin Phosphate
msds (material safety sheet)
Cleocin Phosphate
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Cleocin Phosphate
Molecular Weight
424.984 g/mol
Cleocin Phosphate
Melting Point
255 oC
Cleocin Phosphate
H2O Solubility
30.6 mg/L
Cleocin Phosphate
State
Solid
Cleocin Phosphate
LogP
1.224
Cleocin Phosphate
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Cleocin Phosphate
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Cleocin Phosphate
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Cleocin Phosphate
Absorption
- 90% - oral
Cleocin Phosphate
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Cleocin Phosphate
Patient Information
Cleocin Phosphate
Organisms Affected
Enteric bacteria and other eubacteria