Clindamycin Hydrochloride
Brand names,
Clindamycin Hydrochloride
Analogs
Clindamycin Hydrochloride
Brand Names Mixture
Clindamycin Hydrochloride
Chemical_Formula
C18H33ClN2O5S
Clindamycin Hydrochloride
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Clindamycin Hydrochloride
fda sheet
Clindamycin Hydrochloride
msds (material safety sheet)
Clindamycin Hydrochloride
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Clindamycin Hydrochloride
Molecular Weight
424.984 g/mol
Clindamycin Hydrochloride
Melting Point
255 oC
Clindamycin Hydrochloride
H2O Solubility
30.6 mg/L
Clindamycin Hydrochloride
State
Solid
Clindamycin Hydrochloride
LogP
1.224
Clindamycin Hydrochloride
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Clindamycin Hydrochloride
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Clindamycin Hydrochloride
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clindamycin Hydrochloride
Absorption
- 90% - oral
Clindamycin Hydrochloride
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Clindamycin Hydrochloride
Patient Information
Clindamycin Hydrochloride
Organisms Affected
Enteric bacteria and other eubacteria