Categoria
Isoptimo
Nombres de marca,
Isoptimo
Analogos
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Marca los nombres de mezcla
Tarka (trandolapril + verapamil hydrochloride)
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Formula quimica
C27H38N2O4
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RX enlace
http://www.rxlist.com/cgi/generic/verapsr.htm
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FDA hoja
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MSDS (hoja de seguridad de materiales)
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Sintesis de referencia
Dengel, EE.UU. Pat. 3,261,859 (1966)
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Peso molecular
454.602 g/mol
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Punto de fusion
< 25 oC
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H2O Solubilidad
4,47 mg / L
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Estado
Liquid
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LogP
5.931
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Formas de dosificacion
Cápsulas (liberación sostenida), líquido, solución, Tablet, Tablet (de liberación prolongada)
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Indicacion
Para el tratamiento de la hipertensión y la angina de pecho.
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Farmacologia
Verapamilo, un agente antiarrítmico de clase IV, se utiliza como calcio, bloqueadores de los canales (CCB) agente para el tratamiento de la angina, la hipertensión y las taquiarritmias supraventriculares.
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Absorcion
90%
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Toxicidad
LD50 = 8 mg / kg (iv en ratones)
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Informacion de Pacientes
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
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Organismos afectados
Humanos y otros mamíferos