Trimethobenzamide

Antiemetics

Trimethobenzamide Brand names, Trimethobenzamide Analogs

Trimethobenzamide Brand Names Mixture

No information avaliable

Trimethobenzamide Chemical_Formula

C₂₁H₂₈N₂O₅

Trimethobenzamide RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Trimethobenzamide fda sheet

Trimethobenzamide FDA

Trimethobenzamide msds (material safety sheet)

Trimethobenzamide MSDS

Trimethobenzamide Synthesis Reference

No information avaliable

Trimethobenzamide Molecular Weight

388.458 g/mol

Trimethobenzamide Melting Point

188.7 ^oC

Trimethobenzamide H₂O Solubility

40 mg/L

Trimethobenzamide State

Solid

Trimethobenzamide LogP

2.784

Trimethobenzamide Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Trimethobenzamide Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Trimethobenzamide Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Trimethobenzamide Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Trimethobenzamide side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Trimethobenzamide Patient Information