Mastop

Antiemetics

Mastop Brand names, Mastop Analogs

Mastop Brand Names Mixture

No information avaliable

Mastop Chemical_Formula

C₂₁H₂₈N₂O₅

Mastop RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Mastop fda sheet

Mastop FDA

Mastop msds (material safety sheet)

Mastop MSDS

Mastop Synthesis Reference

No information avaliable

Mastop Molecular Weight

388.458 g/mol

Mastop Melting Point

188.7 ^oC

Mastop H₂O Solubility

40 mg/L

Mastop State

Solid

Mastop LogP

2.784

Mastop Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Mastop Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Mastop Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Mastop Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Mastop side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Mastop Patient Information