Trasamlon

Antiemetics

Trasamlon Brand names, Trasamlon Analogs

Trasamlon Brand Names Mixture

No information avaliable

Trasamlon Chemical_Formula

C₂₁H₂₈N₂O₅

Trasamlon RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Trasamlon fda sheet

Trasamlon FDA

Trasamlon msds (material safety sheet)

Trasamlon MSDS

Trasamlon Synthesis Reference

No information avaliable

Trasamlon Molecular Weight

388.458 g/mol

Trasamlon Melting Point

188.7 ^oC

Trasamlon H₂O Solubility

40 mg/L

Trasamlon State

Solid

Trasamlon LogP

2.784

Trasamlon Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Trasamlon Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Trasamlon Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Trasamlon Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Trasamlon side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Trasamlon Patient Information