Amcha

Antiemetics

Amcha Brand names, Amcha Analogs

Amcha Brand Names Mixture

No information avaliable

Amcha Chemical_Formula

C₂₁H₂₈N₂O₅

Amcha RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Amcha fda sheet

Amcha FDA

Amcha msds (material safety sheet)

Amcha MSDS

Amcha Synthesis Reference

No information avaliable

Amcha Molecular Weight

388.458 g/mol

Amcha Melting Point

188.7 ^oC

Amcha H₂O Solubility

40 mg/L

Amcha State

Solid

Amcha LogP

2.784

Amcha Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Amcha Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Amcha Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Amcha Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Amcha side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Amcha Patient Information