Trans AMCHA

Antiemetics

Trans AMCHA Brand names, Trans AMCHA Analogs

Trans AMCHA Brand Names Mixture

No information avaliable

Trans AMCHA Chemical_Formula

C₂₁H₂₈N₂O₅

Trans AMCHA RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Trans AMCHA fda sheet

Trans_AMCHA FDA

Trans AMCHA msds (material safety sheet)

Trans_AMCHA MSDS

Trans AMCHA Synthesis Reference

No information avaliable

Trans AMCHA Molecular Weight

388.458 g/mol

Trans AMCHA Melting Point

188.7 ^oC

Trans AMCHA H₂O Solubility

40 mg/L

Trans AMCHA State

Solid

Trans AMCHA LogP

2.784

Trans AMCHA Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Trans AMCHA Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Trans AMCHA Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Trans AMCHA Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Trans AMCHA side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Trans AMCHA Patient Information