Anvitoff

Antiemetics

Anvitoff Brand names, Anvitoff Analogs

Anvitoff Brand Names Mixture

No information avaliable

Anvitoff Chemical_Formula

C₂₁H₂₈N₂O₅

Anvitoff RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Anvitoff fda sheet

Anvitoff FDA

Anvitoff msds (material safety sheet)

Anvitoff MSDS

Anvitoff Synthesis Reference

No information avaliable

Anvitoff Molecular Weight

388.458 g/mol

Anvitoff Melting Point

188.7 ^oC

Anvitoff H₂O Solubility

40 mg/L

Anvitoff State

Solid

Anvitoff LogP

2.784

Anvitoff Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Anvitoff Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Anvitoff Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Anvitoff Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Anvitoff side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Anvitoff Patient Information