Amstat

Antiemetics

Amstat Brand names, Amstat Analogs

Amstat Brand Names Mixture

No information avaliable

Amstat Chemical_Formula

C₂₁H₂₈N₂O₅

Amstat RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Amstat fda sheet

Amstat FDA

Amstat msds (material safety sheet)

Amstat MSDS

Amstat Synthesis Reference

No information avaliable

Amstat Molecular Weight

388.458 g/mol

Amstat Melting Point

188.7 ^oC

Amstat H₂O Solubility

40 mg/L

Amstat State

Solid

Amstat LogP

2.784

Amstat Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Amstat Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Amstat Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Amstat Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Amstat side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Amstat Patient Information