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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C9H11N
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RX_link
http://www.rxlist.com/cgi/generic2/tranylcypromine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
133.19 g/mol
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Melting Point
79-80 oC at 1.50E+00 mm Hg
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H2O Solubility
4.86E+004 mg/L
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State
Solid
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LogP
1.434
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Dosage Forms
Tablets (10 mg, for oral administration)
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Indication
For the treatment of major depressive episode without melancholia.
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Pharmacology
Tranylcypromine belongs to a class of antidepressants called monoamine oxidase inhibitors (MAOIs). Tranylcypromine is a non-hydrazine monoamine oxidase inhibitor with a rapid onset of activity. It increases the concentration of epinephrine, norepinephrine, and serotonin in storage sites throughout the nervous system and, in theory, this increased concentration of monoamines in the brain stem is the basis for its antidepressant activity.
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Absorption
No information avaliable
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side effects and Toxicity
In overdosage, some patients exhibit insomnia, restlessness and anxiety, progressing in severe cases to agitation, mental confusion and incoherence. Hypotension, dizziness, weakness and drowsiness may occur, progressing in severe cases to extreme dizziness and shock. A few patients have displayed hypertension with severe headache and other symptoms. Rare instances have been reported in which hypertension was accompanied by twitching or myoclonic fibrillation of skeletal muscles with hyperpyrexia, sometimes progressing to generalized rigidity and coma.
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Patient Information
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Organisms Affected
Humans and other mammals