Ugurol

Antiemetics

Ugurol Brand names, Ugurol Analogs

Ugurol Brand Names Mixture

No information avaliable

Ugurol Chemical_Formula

C₂₁H₂₈N₂O₅

Ugurol RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Ugurol fda sheet

Ugurol FDA

Ugurol msds (material safety sheet)

Ugurol MSDS

Ugurol Synthesis Reference

No information avaliable

Ugurol Molecular Weight

388.458 g/mol

Ugurol Melting Point

188.7 ^oC

Ugurol H₂O Solubility

40 mg/L

Ugurol State

Solid

Ugurol LogP

2.784

Ugurol Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Ugurol Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Ugurol Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Ugurol Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Ugurol side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Ugurol Patient Information