Carxamin

Antiemetics

Carxamin Brand names, Carxamin Analogs

Carxamin Brand Names Mixture

No information avaliable

Carxamin Chemical_Formula

C₂₁H₂₈N₂O₅

Carxamin RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Carxamin fda sheet

Carxamin FDA

Carxamin msds (material safety sheet)

Carxamin MSDS

Carxamin Synthesis Reference

No information avaliable

Carxamin Molecular Weight

388.458 g/mol

Carxamin Melting Point

188.7 ^oC

Carxamin H₂O Solubility

40 mg/L

Carxamin State

Solid

Carxamin LogP

2.784

Carxamin Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Carxamin Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Carxamin Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Carxamin Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Carxamin side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Carxamin Patient Information