Rikavarin

Antiemetics

Rikavarin Brand names, Rikavarin Analogs

Rikavarin Brand Names Mixture

No information avaliable

Rikavarin Chemical_Formula

C₂₁H₂₈N₂O₅

Rikavarin RX_link

http://www.rxlist.com/cgi/generic3/trimethbenz.htm

Rikavarin fda sheet

Rikavarin FDA

Rikavarin msds (material safety sheet)

Rikavarin MSDS

Rikavarin Synthesis Reference

No information avaliable

Rikavarin Molecular Weight

388.458 g/mol

Rikavarin Melting Point

188.7 ^oC

Rikavarin H₂O Solubility

40 mg/L

Rikavarin State

Solid

Rikavarin LogP

2.784

Rikavarin Dosage Forms

Capsules (300 mg) for oral administration; Suppositories (200 mg); Injectable (100 mg, 200 mg)

Rikavarin Indication

For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.

Rikavarin Pharmacology

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.

Rikavarin Absorption

The relative bioavailability of the capsule formulation compared to the solution is 100%.

Rikavarin side effects and Toxicity

Oral LD₅₀ in mice is 1600 mg/kg.

Rikavarin Patient Information