Sodiuretic
Brand names,
Sodiuretic
Analogs
Sodiuretic
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Sodiuretic
Chemical_Formula
C15H14F3N3O4S2
Sodiuretic
RX_link
No information avaliable
Sodiuretic
fda sheet
Sodiuretic
msds (material safety sheet)
Sodiuretic
Synthesis Reference
No information avaliable
Sodiuretic
Molecular Weight
421.417 g/mol
Sodiuretic
Melting Point
221-223 oC
Sodiuretic
H2O Solubility
108 mg/L
Sodiuretic
State
Solid
Sodiuretic
LogP
2.085
Sodiuretic
Dosage Forms
Tablet
Sodiuretic
Indication
For the treatment of high blood pressure and management of edema
Sodiuretic
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Sodiuretic
Absorption
Absorbed relatively rapidly after oral administration
Sodiuretic
side effects and Toxicity
No information avaliable
Sodiuretic
Patient Information
No information avaliable
Sodiuretic
Organisms Affected
Humans and other mammals