Benuron
Brand names,
Benuron
Analogs
Benuron
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Benuron
Chemical_Formula
C15H14F3N3O4S2
Benuron
RX_link
No information avaliable
Benuron
fda sheet
Benuron
msds (material safety sheet)
Benuron
Synthesis Reference
No information avaliable
Benuron
Molecular Weight
421.417 g/mol
Benuron
Melting Point
221-223 oC
Benuron
H2O Solubility
108 mg/L
Benuron
State
Solid
Benuron
LogP
2.085
Benuron
Dosage Forms
Tablet
Benuron
Indication
For the treatment of high blood pressure and management of edema
Benuron
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Benuron
Absorption
Absorbed relatively rapidly after oral administration
Benuron
side effects and Toxicity
No information avaliable
Benuron
Patient Information
No information avaliable
Benuron
Organisms Affected
Humans and other mammals