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Bristuric Brand names, Bristuric Analogs

Bristuric Brand Names Mixture

  • Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
  • Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)

Bristuric Chemical_Formula

C15H14F3N3O4S2

Bristuric RX_link

No information avaliable

Bristuric fda sheet

Bristuric msds (material safety sheet)

Bristuric Synthesis Reference

No information avaliable

Bristuric Molecular Weight

421.417 g/mol

Bristuric Melting Point

221-223 oC

Bristuric H2O Solubility

108 mg/L

Bristuric State

Solid

Bristuric LogP

2.085

Bristuric Dosage Forms

Tablet

Bristuric Indication

For the treatment of high blood pressure and management of edema

Bristuric Pharmacology

Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Bristuric Absorption

Absorbed relatively rapidly after oral administration

Bristuric side effects and Toxicity

No information avaliable

Bristuric Patient Information

No information avaliable

Bristuric Organisms Affected

Humans and other mammals