Neo-Naclex
Brand names,
Neo-Naclex
Analogs
Neo-Naclex
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Neo-Naclex
Chemical_Formula
C15H14F3N3O4S2
Neo-Naclex
RX_link
No information avaliable
Neo-Naclex
fda sheet
Neo-Naclex
msds (material safety sheet)
Neo-Naclex
Synthesis Reference
No information avaliable
Neo-Naclex
Molecular Weight
421.417 g/mol
Neo-Naclex
Melting Point
221-223 oC
Neo-Naclex
H2O Solubility
108 mg/L
Neo-Naclex
State
Solid
Neo-Naclex
LogP
2.085
Neo-Naclex
Dosage Forms
Tablet
Neo-Naclex
Indication
For the treatment of high blood pressure and management of edema
Neo-Naclex
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Neo-Naclex
Absorption
Absorbed relatively rapidly after oral administration
Neo-Naclex
side effects and Toxicity
No information avaliable
Neo-Naclex
Patient Information
No information avaliable
Neo-Naclex
Organisms Affected
Humans and other mammals