Benzylrodiuran
Brand names,
Benzylrodiuran
Analogs
Benzylrodiuran
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Benzylrodiuran
Chemical_Formula
C15H14F3N3O4S2
Benzylrodiuran
RX_link
No information avaliable
Benzylrodiuran
fda sheet
Benzylrodiuran
msds (material safety sheet)
Benzylrodiuran
Synthesis Reference
No information avaliable
Benzylrodiuran
Molecular Weight
421.417 g/mol
Benzylrodiuran
Melting Point
221-223 oC
Benzylrodiuran
H2O Solubility
108 mg/L
Benzylrodiuran
State
Solid
Benzylrodiuran
LogP
2.085
Benzylrodiuran
Dosage Forms
Tablet
Benzylrodiuran
Indication
For the treatment of high blood pressure and management of edema
Benzylrodiuran
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Benzylrodiuran
Absorption
Absorbed relatively rapidly after oral administration
Benzylrodiuran
side effects and Toxicity
No information avaliable
Benzylrodiuran
Patient Information
No information avaliable
Benzylrodiuran
Organisms Affected
Humans and other mammals