Bristuron
Brand names,
Bristuron
Analogs
Bristuron
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Bristuron
Chemical_Formula
C15H14F3N3O4S2
Bristuron
RX_link
No information avaliable
Bristuron
fda sheet
Bristuron
msds (material safety sheet)
Bristuron
Synthesis Reference
No information avaliable
Bristuron
Molecular Weight
421.417 g/mol
Bristuron
Melting Point
221-223 oC
Bristuron
H2O Solubility
108 mg/L
Bristuron
State
Solid
Bristuron
LogP
2.085
Bristuron
Dosage Forms
Tablet
Bristuron
Indication
For the treatment of high blood pressure and management of edema
Bristuron
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Bristuron
Absorption
Absorbed relatively rapidly after oral administration
Bristuron
side effects and Toxicity
No information avaliable
Bristuron
Patient Information
No information avaliable
Bristuron
Organisms Affected
Humans and other mammals