Sinesalin
Brand names,
Sinesalin
Analogs
Sinesalin
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Sinesalin
Chemical_Formula
C15H14F3N3O4S2
Sinesalin
RX_link
No information avaliable
Sinesalin
fda sheet
Sinesalin
msds (material safety sheet)
Sinesalin
Synthesis Reference
No information avaliable
Sinesalin
Molecular Weight
421.417 g/mol
Sinesalin
Melting Point
221-223 oC
Sinesalin
H2O Solubility
108 mg/L
Sinesalin
State
Solid
Sinesalin
LogP
2.085
Sinesalin
Dosage Forms
Tablet
Sinesalin
Indication
For the treatment of high blood pressure and management of edema
Sinesalin
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Sinesalin
Absorption
Absorbed relatively rapidly after oral administration
Sinesalin
side effects and Toxicity
No information avaliable
Sinesalin
Patient Information
No information avaliable
Sinesalin
Organisms Affected
Humans and other mammals