PharmacyCodes



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Corzide Brand names, Corzide Analogs

Corzide Brand Names Mixture

  • Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
  • Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)

Corzide Chemical_Formula

C17H27NO4

Corzide RX_link

http://www.rxlist.com/cgi/generic3/nadolol.htm

Corzide fda sheet

Corzide msds (material safety sheet)

Corzide Synthesis Reference

F. P. Hauck et al., U.S. Pat. 3,935,267 (1976)

Corzide Molecular Weight

309.401 g/mol

Corzide Melting Point

124-136 oC

Corzide H2O Solubility

8330 mg/L

Corzide State

Solid

Corzide LogP

1.398

Corzide Dosage Forms

Tablets (20 mg, 40 mg, 80 mg, 120 mg, and 160 mg)

Corzide Indication

Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension.

Corzide Pharmacology

Nadolol is a nonselective beta-adrenergic receptor antagonist with a long half-life, and is structurally similar to propranolol. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. Nadolol has no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, nadolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.

Corzide Absorption

Absorption of nadolol after oral dosing is variable, averaging about 30 percent.

Corzide side effects and Toxicity

Oral, mouse: LD50 = 4500mg/kg. Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing.

Corzide Patient Information

Patients, especially those with evidence of coronary artery insufficiency, should be warned against interruption or discontinuation of nadolol therapy without the physician's advice. Although cardiac failure rarely occurs in properly selected patients, patients being treated with beta-adrenergic blocking agents should be advised to consult the physician at the first sign or symptom of impending failure. The patient should also be advised of a proper course in the event of an inadvertently missed dose.

Corzide Organisms Affected

Humans and other mammals