Flumesil
Brand names,
Flumesil
Analogs
Flumesil
Brand Names Mixture
- Corzide Tab W Nadolol 40mg (Bendroflumethiazide + Nadolol)
- Corzide Tab W Nadolol 80mg (Bendroflumethiazide + Nadolol)
Flumesil
Chemical_Formula
C15H14F3N3O4S2
Flumesil
RX_link
No information avaliable
Flumesil
fda sheet
Flumesil
msds (material safety sheet)
Flumesil
Synthesis Reference
No information avaliable
Flumesil
Molecular Weight
421.417 g/mol
Flumesil
Melting Point
221-223 oC
Flumesil
H2O Solubility
108 mg/L
Flumesil
State
Solid
Flumesil
LogP
2.085
Flumesil
Dosage Forms
Tablet
Flumesil
Indication
For the treatment of high blood pressure and management of edema
Flumesil
Pharmacology
Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Flumesil
Absorption
Absorbed relatively rapidly after oral administration
Flumesil
side effects and Toxicity
No information avaliable
Flumesil
Patient Information
No information avaliable
Flumesil
Organisms Affected
Humans and other mammals