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Pertofran Brand names, Pertofran Analogs

Pertofran Brand Names Mixture

  • No information avaliable

Pertofran Chemical_Formula


Pertofran RX_link

Pertofran fda sheet

Pertofran FDA

Pertofran msds (material safety sheet)

Pertofran MSDS

Pertofran Synthesis Reference

No information avaliable

Pertofran Molecular Weight

266.381 g/mol

Pertofran Melting Point

214-218 oC

Pertofran H2O Solubility

No information avaliable

Pertofran State


Pertofran LogP


Pertofran Dosage Forms


Pertofran Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Pertofran Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Pertofran Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Pertofran side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Pertofran Patient Information

No information avaliable

Pertofran Organisms Affected

Humans and other mammals