Pertofran
Pertofran Brand names, Pertofran Analogs
Pertofran Brand Names Mixture
- No information avaliable
Pertofran Chemical_Formula
C18H22N2
Pertofran RX_link
http://www.rxlist.com/cgi/generic2/desipram.htm
Pertofran fda sheet
Pertofran msds (material safety sheet)
Pertofran Synthesis Reference
No information avaliable
Pertofran Molecular Weight
266.381 g/mol
Pertofran Melting Point
214-218 oC
Pertofran H2O Solubility
No information avaliable
Pertofran State
Solid
Pertofran LogP
3.87
Pertofran Dosage Forms
Tablet
Pertofran Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression.
Pertofran Pharmacology
Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.
Pertofran Absorption
Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.
Pertofran side effects and Toxicity
Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg
Pertofran Patient Information
No information avaliable
Pertofran Organisms Affected
Humans and other mammals
