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Norpramine Brand names, Norpramine Analogs

Norpramine Brand Names Mixture

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Norpramine Chemical_Formula


Norpramine RX_link

Norpramine fda sheet

Norpramine FDA

Norpramine msds (material safety sheet)

Norpramine MSDS

Norpramine Synthesis Reference

No information avaliable

Norpramine Molecular Weight

266.381 g/mol

Norpramine Melting Point

214-218 oC

Norpramine H2O Solubility

No information avaliable

Norpramine State


Norpramine LogP


Norpramine Dosage Forms


Norpramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Norpramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Norpramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Norpramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Norpramine Patient Information

No information avaliable

Norpramine Organisms Affected

Humans and other mammals