Norpramin
Brand names,
Norpramin
Analogs
Norpramin
Brand Names Mixture
Norpramin
Chemical_Formula
C18H22N2
Norpramin
RX_link
http://www.rxlist.com/cgi/generic2/desipram.htm
Norpramin
fda sheet
Norpramin
msds (material safety sheet)
Norpramin
Synthesis Reference
No information avaliable
Norpramin
Molecular Weight
266.381 g/mol
Norpramin
Melting Point
214-218 oC
Norpramin
H2O Solubility
No information avaliable
Norpramin
State
Solid
Norpramin
LogP
3.87
Norpramin
Dosage Forms
Tablet
Norpramin
Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression.
Norpramin
Pharmacology
Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.
Norpramin
Absorption
Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.
Norpramin
side effects and Toxicity
Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg
Norpramin
Patient Information
No information avaliable
Norpramin
Organisms Affected
Humans and other mammals