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Pertofrane Brand names, Pertofrane Analogs

Pertofrane Brand Names Mixture

  • No information avaliable

Pertofrane Chemical_Formula


Pertofrane RX_link

Pertofrane fda sheet

Pertofrane FDA

Pertofrane msds (material safety sheet)

Pertofrane MSDS

Pertofrane Synthesis Reference

No information avaliable

Pertofrane Molecular Weight

266.381 g/mol

Pertofrane Melting Point

214-218 oC

Pertofrane H2O Solubility

No information avaliable

Pertofrane State


Pertofrane LogP


Pertofrane Dosage Forms


Pertofrane Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Pertofrane Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Pertofrane Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Pertofrane side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Pertofrane Patient Information

No information avaliable

Pertofrane Organisms Affected

Humans and other mammals