Demethylimipramine en es it fr

Demethylimipramine Brand names, Demethylimipramine Analogs

Demethylimipramine Brand Names Mixture

  • No information avaliable

Demethylimipramine Chemical_Formula


Demethylimipramine RX_link

Demethylimipramine fda sheet

Demethylimipramine FDA

Demethylimipramine msds (material safety sheet)

Demethylimipramine MSDS

Demethylimipramine Synthesis Reference

No information avaliable

Demethylimipramine Molecular Weight

266.381 g/mol

Demethylimipramine Melting Point

214-218 oC

Demethylimipramine H2O Solubility

No information avaliable

Demethylimipramine State


Demethylimipramine LogP


Demethylimipramine Dosage Forms


Demethylimipramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Demethylimipramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Demethylimipramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Demethylimipramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Demethylimipramine Patient Information

No information avaliable

Demethylimipramine Organisms Affected

Humans and other mammals