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Desipramin Brand names, Desipramin Analogs

Desipramin Brand Names Mixture

  • No information avaliable

Desipramin Chemical_Formula


Desipramin RX_link

Desipramin fda sheet

Desipramin FDA

Desipramin msds (material safety sheet)

Desipramin MSDS

Desipramin Synthesis Reference

No information avaliable

Desipramin Molecular Weight

266.381 g/mol

Desipramin Melting Point

214-218 oC

Desipramin H2O Solubility

No information avaliable

Desipramin State


Desipramin LogP


Desipramin Dosage Forms


Desipramin Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Desipramin Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Desipramin Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Desipramin side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Desipramin Patient Information

No information avaliable

Desipramin Organisms Affected

Humans and other mammals