Norimipramine en es it fr

Norimipramine Brand names, Norimipramine Analogs

Norimipramine Brand Names Mixture

  • No information avaliable

Norimipramine Chemical_Formula


Norimipramine RX_link

Norimipramine fda sheet

Norimipramine FDA

Norimipramine msds (material safety sheet)

Norimipramine MSDS

Norimipramine Synthesis Reference

No information avaliable

Norimipramine Molecular Weight

266.381 g/mol

Norimipramine Melting Point

214-218 oC

Norimipramine H2O Solubility

No information avaliable

Norimipramine State


Norimipramine LogP


Norimipramine Dosage Forms


Norimipramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Norimipramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Norimipramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Norimipramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Norimipramine Patient Information

No information avaliable

Norimipramine Organisms Affected

Humans and other mammals