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Pentofran Brand names, Pentofran Analogs

Pentofran Brand Names Mixture

  • No information avaliable

Pentofran Chemical_Formula


Pentofran RX_link

Pentofran fda sheet

Pentofran FDA

Pentofran msds (material safety sheet)

Pentofran MSDS

Pentofran Synthesis Reference

No information avaliable

Pentofran Molecular Weight

266.381 g/mol

Pentofran Melting Point

214-218 oC

Pentofran H2O Solubility

No information avaliable

Pentofran State


Pentofran LogP


Pentofran Dosage Forms


Pentofran Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Pentofran Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Pentofran Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Pentofran side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Pentofran Patient Information

No information avaliable

Pentofran Organisms Affected

Humans and other mammals