Desmethylimipramine en es it fr

Desmethylimipramine Brand names, Desmethylimipramine Analogs

Desmethylimipramine Brand Names Mixture

  • No information avaliable

Desmethylimipramine Chemical_Formula


Desmethylimipramine RX_link

Desmethylimipramine fda sheet

Desmethylimipramine FDA

Desmethylimipramine msds (material safety sheet)

Desmethylimipramine MSDS

Desmethylimipramine Synthesis Reference

No information avaliable

Desmethylimipramine Molecular Weight

266.381 g/mol

Desmethylimipramine Melting Point

214-218 oC

Desmethylimipramine H2O Solubility

No information avaliable

Desmethylimipramine State


Desmethylimipramine LogP


Desmethylimipramine Dosage Forms


Desmethylimipramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Desmethylimipramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Desmethylimipramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Desmethylimipramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Desmethylimipramine Patient Information

No information avaliable

Desmethylimipramine Organisms Affected

Humans and other mammals