Desipramine Hcl en es it fr

Desipramine Hcl Brand names, Desipramine Hcl Analogs

Desipramine Hcl Brand Names Mixture

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Desipramine Hcl Chemical_Formula


Desipramine Hcl RX_link

Desipramine Hcl fda sheet

Desipramine_Hcl FDA

Desipramine Hcl msds (material safety sheet)

Desipramine_Hcl MSDS

Desipramine Hcl Synthesis Reference

No information avaliable

Desipramine Hcl Molecular Weight

266.381 g/mol

Desipramine Hcl Melting Point

214-218 oC

Desipramine Hcl H2O Solubility

No information avaliable

Desipramine Hcl State


Desipramine Hcl LogP


Desipramine Hcl Dosage Forms


Desipramine Hcl Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Desipramine Hcl Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Desipramine Hcl Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Desipramine Hcl side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Desipramine Hcl Patient Information

No information avaliable

Desipramine Hcl Organisms Affected

Humans and other mammals