Desimipramine
Desimipramine Brand names, Desimipramine Analogs
Desimipramine Brand Names Mixture
- No information avaliable
Desimipramine Chemical_Formula
C18H22N2
Desimipramine RX_link
http://www.rxlist.com/cgi/generic2/desipram.htm
Desimipramine fda sheet
Desimipramine msds (material safety sheet)
Desimipramine Synthesis Reference
No information avaliable
Desimipramine Molecular Weight
266.381 g/mol
Desimipramine Melting Point
214-218 oC
Desimipramine H2O Solubility
No information avaliable
Desimipramine State
Solid
Desimipramine LogP
3.87
Desimipramine Dosage Forms
Tablet
Desimipramine Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression.
Desimipramine Pharmacology
Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.
Desimipramine Absorption
Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.
Desimipramine side effects and Toxicity
Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg
Desimipramine Patient Information
No information avaliable
Desimipramine Organisms Affected
Humans and other mammals
