Dimethylimipramine en es it fr

Dimethylimipramine Brand names, Dimethylimipramine Analogs

Dimethylimipramine Brand Names Mixture

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Dimethylimipramine Chemical_Formula


Dimethylimipramine RX_link


Dimethylimipramine fda sheet

Dimethylimipramine FDA

Dimethylimipramine msds (material safety sheet)

Dimethylimipramine MSDS

Dimethylimipramine Synthesis Reference

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Dimethylimipramine Molecular Weight

266.381 g/mol

Dimethylimipramine Melting Point

214-218 oC

Dimethylimipramine H2O Solubility

No information avaliable

Dimethylimipramine State


Dimethylimipramine LogP


Dimethylimipramine Dosage Forms


Dimethylimipramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Dimethylimipramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Dimethylimipramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Dimethylimipramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Dimethylimipramine Patient Information

No information avaliable

Dimethylimipramine Organisms Affected

Humans and other mammals